Monday, 14 January 2019
Tuesday, 8 January 2019
Considerations for Successful Scale-Up To Tox Batches And Phase-Api (Bulk Drugsubstance): LOJMS - Lupine Publishers
Considerations for Successful Scale-Up To Tox Batches And Phase-Api (Bulk Drugsubstance) by Krishna Sarma Pathy in LOJ Medical Sciences (LOJMS) in Lupine publishers
Practical Considerations in Pharmaceutical Production Scale-Up- This paper is meant to provide a high-level overview of the steps required to prepare the bulk drug substance API. From first-in-human and through each of the clinical trial stages and into commercialization, scale-up of formulation design is a natural part of pharmaceutical development. At each stage of process development, the batch size increases, from laboratory-scale batches that may be quite small to support preclinical and early clinical stages, to pilot batches that are used in process development, and finally to the production-scale batches needed to support commercialization Lupine publishers.
For more information click on below link
https://lupinepublishers.com/medical-science-journal/pdf/LOJMS.MS.ID.000112.pdf
https://lupinepublishers.com/medical-science-journal/fulltext/considerations-for-successful-scale-up-to-tox-batches-and-phase-api.ID.000112.php
https://lupinepublishers.com/medical-science-journal/abstracts/considerations-for-successful-scale-up-to-tox-batches-and-phase-api.ID.000112.php
https://lupinepublishers.com/medical-science-journal/fulltext/considerations-for-successful-scale-up-to-tox-batches-and-phase-api.ID.000112.php
https://lupinepublishers.com/medical-science-journal/abstracts/considerations-for-successful-scale-up-to-tox-batches-and-phase-api.ID.000112.php
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Thursday, 27 December 2018
Fungus in the Feet: (LOJMS)- Lupine Publishers
Figure 1 Rich or poor, clean or dirty, infections are always
attacking the feet. Here are verrucas which were treated by the
local doctor with a freezing spray and ointment and for two years
nothing happened until they were zapped with 100 shocks on each
verruca, energy level 3 with a 20 mm focal head.
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Monday, 24 December 2018
Considerations for Successful Scale-Up To Tox Batches And Phase-Api (Bulk Drugsubstance): LOJMS- Lupine Publishers
Considerations for Successful Scale-Up To Tox Batches And Phase-Api (Bulk Drugsubstance) by
Krishna Sarma Pathy in LOJ Medical Sciences in Lupine Publishers
Krishna Sarma Pathy in LOJ Medical Sciences in Lupine Publishers
Practical Considerations in Pharmaceutical Production Scale-Up- This
paper is meant to provide a high-level overview of
the steps required to prepare the bulk drug substance API. From
first-in-human and through each of the clinical trial stages and
into commercialization, scale-up of formulation design is a natural part
of pharmaceutical development. At each stage of process
development, the batch size increases, from laboratory-scale batches
that may be quite small to support preclinical and early
clinical stages, to pilot batches that are used in process development,
and finally to the production-scale batches needed to support
commercialization.
https://www.lupinepublishers.com/medical-science-journal/abstracts/considerations-for-successful-scale-up-to-tox-batches-and-phase-api.ID.000112.php
https://www.lupinepublishers.com/medical-science-journal/fulltext/considerations-for-successful-scale-up-to-tox-batches-and-phase-api.ID.000112.php
https://www.lupinepublishers.com/downloadPdf.php?folder=medical-science-journal&file=LOJMS.MS.ID.000112
https://www.lupinepublishers.com/medical-science-journal/fulltext/considerations-for-successful-scale-up-to-tox-batches-and-phase-api.ID.000112.php
https://www.lupinepublishers.com/downloadPdf.php?folder=medical-science-journal&file=LOJMS.MS.ID.000112
For more medical sciences journals click the below link
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Tuesday, 18 December 2018
The ins and outs of elimination: (LOJMS) - Lupine Publishers
The ins and outs of elimination by Andrew Hague in LOJ Medical Sciences (LOJMS) in Lupine Publishers
The interdependence of all living things affects human health. Food is more than energy alone. There are varieties of minerals
that are balanced by the body according to its needs and what it does not need is expelled. If they remain, they cause problems - Lupine Publishers.
For more information click the below links
https://www.lupinepublishers.com/medical-science-journal/fulltext/the-ins-and-outs-of-elimination.ID.000111.php
https://www.lupinepublishers.com/medical-science-journal/abstracts/the-ins-and-outs-of-elimination.ID.000111.php
https://www.lupinepublishers.com/medical-science-journal/pdf/LOJMS.MS.ID.000111.pdf
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For more medical sciences journals click the below link
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Sunday, 9 December 2018
Cefpodoxime Proxetil and its By-Products: A Comparative Study as Per EP-7: (LOJMS) - Lupine Publishers)
Cefpodoxime Proxetil and its By-Products: A Comparative Study as Per EP-7 by Krishnasarma pathy in LOJ Medical Sciences - LupinePublishers
Cephalosporins are the highly used Broad-spectrum antibiotics, belong to
β-lactam class. Cephalosporins resemble penicillin
in that they have a β-lactam structure, but the five-member thiazolidine
ring characteristic of the penicillin is replaced by a sixmember
dihydrothiazine ring. The bactericidal action of beta lactam antibiotics
is directly attributable to their ability to react with
PBP’s. The research work relates to a by-products during process for the
industrial manufacture of Cefpodoxime Proxetil. The
drug is registered in USP and belongs to 3rd generation drug. It was
discovered by Brotzu in fungus Cephalosporium Acremonium
which produces a chemical which show antimicrobial activity. Abraham
isolated the three fragmentation patterns of cefpodoximeproxetil. Data from this systematic study will help improve the safety
and quality of cefpodoxime proxetil types of cephalosporin
antibiotics cephalosporin P, cephalosporin N, cephalosporin C.7-ACA is
widely used as the substrate for synthesizing cephalosporinantibiotics. Modification of the 7-ACA side-chains resulted in the
development of useful antibiotic agents, and the first agent is
Cephalothin (cefalotin) was launched by. Eli Lilly Company in 1964 There
are many patents which gives the procedure of Synthesis
of Cefpodoxime ProxetilStability of three Cefpodoxime proxetil products
available in indian market at fridge temperatures (2-8 °C),
room temperature (25 °C) and elevated temperature (42 °C). Flow
properties, rheological and the physicochemical parameters of
both powder and reconstituted powder were used to evaluate the stability
of different brands of Cefpodoxime proxetil available in
india. The powder of stability samples was eluted through a C18 column
with formic acid-methanol-water as the mobile phase. In
total, 15 impurities were characterized in commercial samples, including
7 known impurities and 8 new impurities. The structures
of these unknown compounds were deduced via comparison in Lupine Publishers.
For more information click the below Link
https://www.lupinepublishers.com/medical-science-journal/fulltext/cefpodoxime-proxetil-and-its-by-products-a-comparative-study-as-per-ep-7.ID.000110.php
https://www.lupinepublishers.com/medical-science-journal/abstracts/cefpodoxime-proxetil-and-its-by-products-a-comparative-study-as-per-ep-7.ID.000110.php
https://www.lupinepublishers.com/medical-science-journal/pdf/LOJMS.MS.ID.000110.pdf
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Monday, 3 December 2018
Doctors should be paid more: (LOJMS) - Lupine Publishers
Doctors should be paid more by Andrew Hague in LOJ Medical Sciences (LOJMS) - Lupine Publishers
Only by increasing productivity can earnings be increased. This applies to doctors as much as all trades. Better techniquesenable diseases to be cured that have hitherto been impossible by traditional methods. By these means, a doctor can heal more patients more easily. Thus, a doctor can earn more, and patients be charged less in Lupine Publishers.
For more Information click the below link
https://www.lupinepublishers.com/medical-science-journal/pdf/LOJMS.MS.ID.000109.pdf
For more Lupine Open Access Journals click the below link
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