Cefpodoxime Proxetil and its By-Products: A Comparative Study as Per EP-7 by Krishnasarma pathy in LOJ Medical Sciences - LupinePublishers
Cephalosporins are the highly used Broad-spectrum antibiotics, belong to
β-lactam class. Cephalosporins resemble penicillin
in that they have a β-lactam structure, but the five-member thiazolidine
ring characteristic of the penicillin is replaced by a sixmember
dihydrothiazine ring. The bactericidal action of beta lactam antibiotics
is directly attributable to their ability to react with
PBP’s. The research work relates to a by-products during process for the
industrial manufacture of Cefpodoxime Proxetil. The
drug is registered in USP and belongs to 3rd generation drug. It was
discovered by Brotzu in fungus Cephalosporium Acremonium
which produces a chemical which show antimicrobial activity. Abraham
isolated the three fragmentation patterns of cefpodoximeproxetil. Data from this systematic study will help improve the safety
and quality of cefpodoxime proxetil types of cephalosporin
antibiotics cephalosporin P, cephalosporin N, cephalosporin C.7-ACA is
widely used as the substrate for synthesizing cephalosporinantibiotics. Modification of the 7-ACA side-chains resulted in the
development of useful antibiotic agents, and the first agent is
Cephalothin (cefalotin) was launched by. Eli Lilly Company in 1964 There
are many patents which gives the procedure of Synthesis
of Cefpodoxime ProxetilStability of three Cefpodoxime proxetil products
available in indian market at fridge temperatures (2-8 °C),
room temperature (25 °C) and elevated temperature (42 °C). Flow
properties, rheological and the physicochemical parameters of
both powder and reconstituted powder were used to evaluate the stability
of different brands of Cefpodoxime proxetil available in
india. The powder of stability samples was eluted through a C18 column
with formic acid-methanol-water as the mobile phase. In
total, 15 impurities were characterized in commercial samples, including
7 known impurities and 8 new impurities. The structures
of these unknown compounds were deduced via comparison in Lupine Publishers.
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